NIH R01 · 2025
Investigating the pro-regenerative potential of Pontin in the heart.
Project Summary Ischemic heart disease is the leading cause of death worldwide, in part because human heart muscle fails to regenerate after ischemic injury. A primary barrier to human heart regeneration is the near-complete absence of cardiomyocyte cell division following a myocardial infarction (MI). Fortuitously, injured hearts of adult zebrafish and neonatal mice are capable of robust cardiac regeneration achieved through cardiomyocyte proliferation. However, neonatal mice lose their innate cardiac regenerative capacity between P1 and P7 due to cardiomyocyte cell cycle exit, the regulatory details of which remain incompletely understood. Deciphering the pro- and anti-proliferative…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.