NIH R01 · 2024
Inflammation and EGFR crosstalk in HNSCC Therapy
Project Summary Given the importance of oncogenic epidermal growth factor receptor (EGFR) signaling for tumor cell proliferation in head and neck squamous cell carcinoma (HNSCC), we believe that EGFR inhibition remains worthy as a strategy to be included in radiotherapy (RT) protocols for HNSCC and that further investigation of mechanisms responsible for poor response to EGFRIs is warranted. Based on our preliminary data, we propose that increased interleukin-1 (IL-1) signaling may lead to sustained interleukin-8 (IL-8) signaling and NADPH oxidase 2 (NOX2)-derived superoxide (O2.-) production which is associated with pro-survival signaling and an immunosuppressive tumor microenvironment…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.