NIH R01 · 2024
C. officinalis induction of Nrf2 inhibiting type 1 diabetes
7. Project Summary/Abstract Type 1 diabetes (T1D) is an autoimmune disease initiated by genetic predisposition and environmental influences culminating in the destruction of pancreatic β-cells with irreversible loss of insulin production. Despite strong predictive biomarkers of T1D, there is no cure and only one recently approved interventional therapy with moderate effects. Therefore, identification and development of novel T1D interventional therapeutics are needed and explored in this proposal. A potential source for novel interventional therapies is from the frequently used Cornus officinalis (CO) in the field of ethnopharmacology. We have recently shown that CO could inhibit cytokine…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.