NIH R01 · 2025
Deciphering innate and adaptive immune responses to Rickettsia parkeri
PROJECT SUMMARY/ABSTRACT Tick-borne Rickettsia species cause serious human disease in the United States and worldwide, including spotted fever and typhus, with no approved vaccines and an increasing incidence of infection. R. rickettsii is the causative agent of Rocky Mountain spotted fever, and the closely related R. parkeri causes spotted fever in North and South America. However, due to their obligate intracellular nature and technical challenges, the interactions between Rickettsia and innate and adaptive immunity remain largely unclear. Elucidating how Rickettsia evade innate immunity and stimulate an adaptive response is critical for developing effective vaccines and therapeutics to…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.