Avril Lab

Case Western Reserve University

PATHOLOGY

Cleveland · United States

NIH-funded
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Research focus

NIH R01 · 2024

The Microbiome and Mucosal Immunity in Cervical Cancer Disparities

The microbiome and mucosal immunity in cervical cancer disparities African American women living in the United States continue to experience an undue higher burden of cervical cancer and a >2 times higher mortality rate than European American women. This survival disparity persists after accounting for socioeconomic status and disease stage. The presence of high-risk human papillomavirus (HPV) is the major cause of cervical cancer and cervical intraepithelial neoplasia. Prophylactic vaccines are available against the most carcinogenic types and are highly effective, but disparities persist and the number of people receiving the vaccine remains suboptimal especially for African American…

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