NIH R01 · 2024
Function of Sequence-specific RNA Binding Proteins
Summary Alternative splicing is nearly universal in human genes, producing multiple distinct mRNAs and proteins from each individual gene locus. This process is regulated by over one hundred splicing factors that bind to specific RNA motifs in the primary transcript and modulate splicing by interaction with core splicing machinery or with other splicing factors. This proposal seeks to understand the rules that govern the activities of splicing factors. Each splicing factor's activity can be summarized by an RNA map that describes how its activity depends on location of binding relative to the regulated exon or splice sites. It is organized around the following aims. SA1. To develop and test…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.