NIH R01 · 2025
Engineered Granular Hydrogels for Endogenous Tissue Repair
Abstract Myocardial infarction (MI) and the resulting left ventricular remodeling may compromise cardiac function and eventually result in heart failure. Although there are limited current treatment options for these patients beyond re-perfusion, a number of biomaterial therapies are currently being developed and have even progressed to clinical trials. Our lab with our clinical collaborators have been exploring the use of injectable hydrogels for over a decade to provide both mechanical and biological signals to the heart during the acute phase of MI, to alter the LV remodeling response and to improve cardiac function. Often, these hydrogels are delivered as a “pocket” of material within…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.