Bunnik Lab

Research focus

NIH R01 · 2024

Defining conserved epitopes on polymorphic malaria antigens

PROJECT SUMMARY Malaria is still responsible for an estimated 429,000 deaths and 212 million infections per year, the large majority among young children. Individuals living in endemic regions gradually develop an immune response that protects against symptomatic disease. Naturally acquired immunity targets the blood stage of the parasite’s life cycle and is largely dependent on antibody reactivity. Elicitation of a similar immune response by vaccination in young, non-immune children would dramatically reduce malaria morbidity and mortality. Various parasite antigens have been associated with protection against clinical disease. Most of these antigens are expressed in the merozoite stage…

From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.