NIH R01 · 2024
Influences of DNA sequence and histone features on transcription factor binding to nucleosomes
Abstract Gene expression programs are dynamically regulated by the accessibility of chromatin for transcription factor (TF) binding, but how TFs recognize specific regulatory regions occluded by nucleosomes remains unclear. Certain TFs, termed pioneer factors, can recognize their target sites within nucleosomes, leading to the opening of chromatin. By priming cis-regulatory elements for subsequent transcriptional regulatory activity, pioneers serve as gatekeepers to cellular differentiation. Although pioneers can bind nucleosomal sites, they bind only a subset of their potential recognition sites in the genome that typically varies across cell types, thus indicating their interplay with…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.