NIH R01 · 2025
The STAT3 Pathway in Uterine Leiomyoma: A Therapeutic Target
ABSTRACT/SUMMARY Uterine leiomyomas (LMs, fibroids) are the most important neoplastic threat to women worldwide. As no long- term non-invasive treatment option exists for LMs, deeper insight into tumor etiology is key to develop more effective medical therapies. Accordingly, this proposal is impactful as it suggests a novel etiological basis for the predominant MED12-mutated LM subtype and offers proof of concept for therapeutic intervention in this specific genetic setting. LMs arise from recurrent and mutually exclusive genetic alterations in a limited number of driver genes. Among these, mutations in the RNA Polymerase II Mediator subunit MED12 (mut-MED12) are by far the most prevalent,…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.