NIH R01 · 2024
Environmental Pollutants and AHR pathway in Uterine Leiomyoma
Uterine leiomyomas (LM, fibroids) disrupt uterine function and cause recurrent pregnancy loss, excessive uterine bleeding, and anemia in 15-30% of reproductive-age women. No long-term medical treatment is available. Understanding how a LM develops is essential for identifying new non-surgical treatments. MED12 mutations (mut-MED12) occur in 70% of all LM and drive LM growth in a steroid hormone-dependent manner. Pre- and peri-menopausal women are widely exposed to endocrine disrupting chemicals (EDCs), e.g., phthalates, which are found in many consumer products and associated with a number of reproductive diseases. How a mut- MED12 influences LM growth and whether this process is enhanced…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.