NIH R01 · 2025
Mouse Models of Human Cancer Database
PROJECT SUMMARY/ABSTRACT The laboratory mouse is the preeminent animal model system for investigation into the biology and genetics of human cancer. Mouse models have provided key insights into cancer susceptibility, the molecular genetics of tumor suppressor and oncogenes, and therapy response in pre-clinical and co-clinical studies. Human tumors engrafted into immune compromised and humanized mice (aka, Patient Derived Xenografts) are playing an increasingly important role as a powerful preclinical platform for testing new cancer treatments. The Mouse Models of Human Cancer (MMHC) database is a unique on-line compendium of mouse models for human cancer. MMHCdb provides electronic access…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.