Buka Lab

Brown University

PUBLIC HEALTH & PREV MEDICINE

Providence · United States

NIH-funded
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NIH R01 · 2025

Early Developmental Risk for Adult Cardiovascular Disease: High risk Subgroups, Biomarkers, and Mechanisms

This project seeks to generate new insights – of clinical and public/health/relevance – regarding the early identification and prevention of adult coronary heart disease (CHD). It is well known that 10% of infants born small for gestational age (SGA), compared to average for gestational infants (AGA), are at increased risk for later life CHD and cardiovascular disease (CVD) mortality. However, there is substantial heterogeneity in these findings and it is not clear: a) which SGA infants are at elevated risk; and b) which underlying pathobiologic mechanisms are implicated. Based upon our published work and those of others, we hypothesize that fetal programming related to placental…

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