NIH R01 · 2024
The role of Fli1 in myeloid cells and its contribution to cardiac fibrosis
ABSTRACT Heart disease is the leading cause of death in the USA and fibrosis is a common endpoint for most cardiac diseases. Recent research has shown monocytes and macrophages are important mediators of heart fibrosis. We found reduced levels of the transcription factor Fli1 in monocytes isolated from systemic sclerosis (SSc) patients, an autoimmune connective tissue disease characterized by widespread tissue fibrosis and fibrotic cardiomyopathy. Co-culture of human cardiac fibroblasts and Fli1 depleted monocytes resulted in potent induction of galectin-3, and alternative activation markers in myeloid cells, and abundant collagen deposition by fibroblasts, and this was blocked by the mTOR…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.