NIH R01 · 2025
A molecular toolbox for thermal control of programmed cell death in animals
Summary/Abstract The objective of this proposal is to develop a molecular toolbox for non-invasive methods to kill cells in situ via specific cell death pathways using safe, penetrant, and tunable temperature stimuli. There is an urgent need for new technology that can engage specific forms of cell death in vivo in a manner that is controlled in space, time, and magnitude. Such technology would enable researchers to systematically interrogate the distinct physiological consequences of programmed cell death through apoptosis, necroptosis, or pyroptosis, and to harness immunogenic types of cell death for cancer therapy. However, current methods to stimulate cell death are either not specific…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.