Buffington Lab

Baylor College of Medicine

NEUROSCIENCES

Houston · United States

NIH-funded
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Research focus

NIH R01 · 2025

Targeting opportunistic pathogens to improve maternal obesity-associated health outcomes in offspring

Maternal prepregnancy obesity predisposes offspring to cognitive dysfunction, yet little is known about the mechanisms underlying the transgenerational effects of maternal obesity on offspring brain function and behavior. This traditionally overlooked cognitive health problem is exacerbated by social determinants of health, given that women of disadvantaged socioeconomic status are disproportionately affected by obesity. Currently, there is no consensus on antenatal care for women with prepregnancy obesity or their infants, and new therapies are needed to prevent chronic disease burden in affected children. Genetic and nongenetic factors contribute to obesity; yet, epidemiological studies…

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