NIH R01 · 2025
Project Summary Lead (Pb) poisoning is a persistent health issue in the United States due to legacy contamination from Pb-based sources such as paint, plumbing, and gasoline. Children are most susceptible to Pb poisoning, which causes persistent cognitive deficits and low IQ. The specific mechanisms by which Pb poisoning impacts development are not fully understood, however. Previous research showed that Pb impacts several thyroid hormone (TH)-related processes, including decreases in expression of TH distributor proteins (THDPs) in the choroid plexus. This is an important issue because TH is a critical regulator of brain development; disrupted TH signaling in utero leads to smaller brain…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.