NIH R01 · 2024
Exploration of MRI measures of neurodegeneration within individuals over short intervals
PROJECT ABSTRACT/SUMMARY Alzheimer's disease and other forms of dementia affect over five million Americans. Alzheimer's disease begins with changes in the brain more than a decade before the disease can be diagnosed from memory and cognitive impairment in a clinic. The goal of this work is to provide a way to measure early signs of neurodegeneration in individual people. The historical barrier to measure change in individuals is that each person's brain is different with change accumulating too slowly to be picked over short intervals. As a result, most research focuses on tracking averaged subject groups or tracking change over multiple years. The present work optimizes new brain imaging…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.