NIH R01 · 2024
Ligand activation of Eph receptors plays a decisive role in cell migration during blood vessel formation and neuronal axon guidance. Eph receptors can also signal independently of ligands, whereby the migration- and adhesion-repulsive signaling shifts to a pro-migratory stimulus that contributes to metastasis and drug resistance in various cancers. Recent studies have substantiated the role of Eph receptors in the dysfunction of the blood brain barrier (BBB) during ischemic stroke, invasion of pathogenic organisms and the early stages of Alzheimer’s Disease (AD) and other neurodegenerative diseases. Yet, the molecular mechanisms behind Eph receptor function remain poorly understood. Eph…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.