NIH R01 · 2024
Gut microbes modulate immune pathways in intestinal stem cells to influence their lineage
An increasing number of epidemiological studies suggest that intestinal microbes are not only central to maintaining host health, but also constitute etiological factors for the initiation and progression of diseases of the intestinal tract. However, the mechanisms by which microbes affect intestinal health remain largely unknown. Using a powerful genetic model organism, Drosophila melanogaster, we have recently shown that microbes not only alter intestinal stem cell (ISC) proliferation, but also modulate the relative proportions of differentiated cell types in the epithelium. Importantly, we found that pathogens promote an enteroendocrine (EE) fate while non- pathogenic microbes promote an…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.