NIH R01 · 2025
Mechanisms of cell fate specification and competence regulation in photoreceptors
PROJECT SUMMARY: Age-related macular degeneration and several other diseases can cause rod and cone photoreceptors to die. This results in permanent visual impairment because the human retina does not regenerate itself. One potential way to restore vision is by replacing the lost photoreceptors. Audacious strategies to restore vision include reprogramming the diseased retina to regenerate its own photoreceptors and directly replacing the lost photoreceptors from stem cell sources. Implementing these strategies requires specific and efficient methods of programming cells to become rods and cones. However, we face a major barrier to achieving these therapeutic strategies due to our limited…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.