NIH R01 · 2024
Bioinspired Mechanically Stiff Hydrogels for Osteochondral Tissue Regeneration
Lesions to articular cartilage and underlying subchondral bone eventually lead to osteoarthritis, a debilitating disease with no cure. A successful therapy will need to promote tissue regeneration, support integrative repair, and protect the surrounding tissue from further degeneration. The overarching goal for this project is to develop a mechanically competent, stem cell-based regenerative approach to treat osteochondral (OC) defects. During the initial funding period, our team developed an OC-mimetic hydrogel with a design that decoupled the load- bearing (i.e., structural) component from the soft cellular biomimetic component. This allowed us to create a functionally graded, stiff…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.