NIH R01 · 2024
Pathogenic monocyte response to chronic lung inflammation in cystic fibrosis
PROJECT SUMMARY Researchers still do not understand the mechanisms behind the progressive and irreversible lung structural damage that ultimately causes respiratory failure in patients with cystic fibrosis (CF). We have developed a CF mouse model of chronic inflammation that recapitulates the progressive and irreversible lung tissue remodeling in late-stage CF lung disease. The overall goal here is to understand the cellular mechanisms that lead to progressive and irreversible CF lung deterioration. The objective is to study how inflammatory monocytes and monocyte-derived MΦs (MΦs) contribute to the development of irreversible lung tissue remodeling in CF. Our central hypothesis is that, in…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.