NIH R01 · 2025
Therapeutic targeting the host hypoxia-response pathway to treat Mucormycosis
PROJECT SUMMARY/ABSTRACT Mucormycosis is a deadly invasive infection caused by several fungal species belonging to the order Mucorales. The major risk factors include uncontrolled diabetes mellitus that results in hyperglycemia and ketoacidosis (DKA), other forms of acidosis, treatment with corticosteroids, solid organ or bone marrow transplantation, neutropenia, trauma and burns (e.g., wounded soldiers in Iraq and Afghanistan), malignant haematological disorders and deferoxamine therapy in patients receiving haemodialysis. The infection is generally acquired by inhalation of spores that are ubiquitous in nature and cause either rhino-orbital (almost exclusively in DKA patients) or…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.