NIH R01 · 2025
A tRNA synthetase is an amino acid sensor for TOR in plants
PROJECT SUMMARY TARGET OF RAPAMYCIN (TOR) is a deeply conserved protein kinase that regulates eukaryotic metabolism. TOR senses and integrates upstream signals, especially nutrient availability, to coordinate metabolism and promote growth only when conditions are favorable. TOR dysregulation causes or contributes to a broad range of human diseases, including cancers, age-related health disorders, and metabolic disorders, which are the major causes of morbidity and mortality in the United States. Therefore, a major goal for biomedical research is to develop therapeutic treatments that specifically target components of the TOR signaling network without broadly disrupting metabolism and…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.