NIH R01 · 2025
The immunobiological mechanisms of depression in perimenopause
PROJECT SUMMARY/ABSTRACT This project aims to identify immunobiological mechanisms underlying the development of depression during the perimenopause, in response to the NIMH funding opportunity “Mood and Psychosis Symptoms during the Menopause Transition”. During the perimenopause, the risk for recurrence of depression is increased 13-fold among women who previously had depression. Moreover, perimenopause overlaps with the age span exhibiting the highest suicide rate for women. The perimenopause can last for several years and starts when estrogen and progesterone levels begin to fluctuate, gradually declining. Sex hormones are powerful modulators of the immune response and we therefore…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.