NIH R01 · 2025
Molecular mechanisms of progranulin as a regulator of endothelial biology and blood pressure control
ABSTRACT Endothelial cell (EC) dysfunction initiates the development of hypertension (HTN), but the mechanisms are not fully elucidated. Given that HBP is the leading cause of cardiovascular diseases, it is critical to identify new opportunities to restore EC function in HTN. In a series of supportive preliminary studies, we identified progranulin (PGRN), an anti-inflammatory protein, as a novel regulator of EC function and BP. We recently published that PGRN deficiency induces vascular dysfunction and HTN, whereas treatment with recombinant PGRN (rPGRN) restores these cardiovascular outcomes via EphrinA2 and nitric oxide (NO) production. In this proposal, we are extending our knowledge on…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.