NIH R01 · 2025
Decoding Locus Coeruleus Neural Circuits and Signaling In Negative Affect
Abstract: Acute stress and threat produce physiological anxiety to facilitate planning and allow for organisms to tune behavior for exploration of the environment, thus serving to promote hyperarousal, anxiogenic-like behavior and avoidance (i.e. aversive responses). Stress is also directly linked to numerous mental health diseases and these disorders currently affect ~30% of the US population. The locus coeruleus (LC) noradrenergic (NE) system and its related GPCRs have been implicated in numerous stress-related affective disorders including, anxiety, hyperarousal and negative affect. The LC-NE system is a critical component for integration of stress-induced avoidance. Our recent evidence…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.