NIH R01 · 2025
Single Cell Analysis of the Infiltrative Margins of Glioblastoma and Post Treatment Recurrence
PROJECT SUMMARY Glioblastoma (GBM) is a deadly form of malignant glioma against which conventional targeted therapies and immunotherapies have had limited success. Both intratumoral heterogeneity and the complexities of drug delivery in the brain are formidable challenges in neuro-oncology, while the “immune cold” nature of these tumors poses challenges to immunotherapy. We recently discovered that acute tissue slices of human GBM surgical specimens recapitulate the detailed cellular and molecular features of glioma tissue and that, when combined with single-cell RNA-seq, can be used to identify cellular subpopulations that are sensitive to a given drug. These models are particularly…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.