NIH R01 · 2025
Simultaneous PET/phMR studies on interplay of mGlu/dopamine receptors in PD-like neurodegeneration
ABSTRACT Research of the brain receptor functions holds a promise to provide better diagnostic tools and drugs that could be tailored for the individual needs, thereby eliminating or reducing side effects and even providing a way for prevention of diseases. Increasing understanding of receptor functions is revealing complex and dynamic interactions between neurotransmitter systems. In the basal ganglia, dopamine (DA) regulation of glutamate (Glu) neurotransmission is complex and the loss of DA-mediated inhibition in the striatum f. ex. in Parkinson disease (PD) results in an imbalance of other neurotransmitters, mostly excitatory. Metabotropic glutamate receptors (mGluR)s are activated when…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.