NIH R01 · 2024
Effects of Aerobic Exercise on Skeletal Muscle Remodeling in Colon Cancer
PROJECT SUMMARY/ABSTRACT Postdiagnosis physical activity is associated with a lower risk of cancer recurrence and death in colon cancer survivors. However, the biological mechanisms that underpin the effects of physical activity on cancer recurrence and death are poorly understood. Skeletal muscle is the most abundant tissue in the human body, representing 40% of body weight and 30% of basal energy expenditure. Skeletal muscle fat infiltration, known as myosteatosis, is an ectopic triglyceride depot that causes insulin resistance and inflammation. One in three colon cancer survivors has myosteatosis. Myosteatosis increases the risk of cancer recurrence, cardiovascular disease, and death in…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.