NIH R01 · 2025
Synaptic Mechanisms of Continuous Theta Burst Stimulation in Depression
PROJECT SUMMARY/ABSTRACT FDA-cleared repetitive transcranial magnetic stimulation (rTMS) protocols are known to increase cortical excit- ability in treatment-resistant depression, but for safety and tolerability reasons, many patients receive TMS pro- tocols designed to “quiet” overactive brain networks. Despite their common clinical and research use, we know very little of their mechanism of action, and consequently, improvements in such protocols have been limited. Inhibition induced by continuous theta burst stimulation (cTBS), perhaps the best studied inhibitory rTMS proto- col, is most likely accomplished through either reducing excitation via n-methyl-d-aspartate receptor…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.