NIH R01 · 2024
Protein phosphorylation and growth factor function
Project Summary/Abstract The emerging Hippo pathway plays a major role in development, cell growth, tissue homeostasis, and organ size. Dysregulation of Hippo pathway contributes to human diseases, most notably cancer. TCGA study with analysis of over nine thousand human tumor samples has revealed that Hippo is one of the nine signals pathways that are frequently altered and contributes to human cancer. The Hippo pathway consists a kinase cascade that phosphorylates and inhibits the downstream transcription module of YAP/TAZ. A wide range of signals have been discovered to modulate the Hippo pathway. However, the precise mechanism of Hippo pathway regulation, particularly how upstream…
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