NIH R01 · 2024
Mechanisms of non-IgE Mast Cell Activation by Environmental Particulates
PROJECT SUMMARY Inflammation is recognized as a major underlying mechanism for a number of diseases with an environmental etiology that have serious pathologic outcomes such as autoimmunity, cancer, cardiovascular disease, lung disease, neurodegeneration as examples. Mast cells represent a major sensory arm of the body's innate immune system by functioning as environmental `sensors' to communicate with other physiological and/or immune responses due to their widespread tissue presence at mucosal surfaces, near blood vessels and the nervous system. Through funding from R01 ES019311, we have begun to unravel novel mechanisms of non- IgE mast cell activation that contribute to inflammation.…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.