NIH R01 · 2025
Mast Cell Activation as a Common Mechanism of Pulmonary Toxicity by Chemical Threat Agents
Project Abstract The Department of Homeland Security considers numerous chemical threat agents a concern for human health, specifically those that are acute pulmonary toxicants. In acute lung injury, inflammation is critical thus we propose that inflammation is a common mechanism of lung injury caused by chemical threat agents due to mast cell activation. We and others have shown mast cell activation to be critical in response to a wide range of xenobiotics including nitrogen mustard, ozone, diesel exhaust, insecticides/herbicides, cigarette smoke, heavy metals and nanoparticles as examples. Mast cells are a logical cell type to study in pulmonary injury from chemical threat agents due to…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.