NIH R01 · 2025
Role of Disadvantage, Mutographs and T Cell Immunity on MGUS in African Americans
ABSTRACT The goal of this investigation is to characterize the influence of structural racism on associations of mutational signatures and T cell immunity on the excess risk of monoclonal gammopathy of undetermined significance (MGUS) observed in African American (AA) populations. MGUS is a necessary precursor to Multiple Myeloma (MM), which is the most common blood cancer affecting AA populations. Despite the increased incidence, 5-year survival is similar by African and European ancestry suggesting that underlying differences in driver events accumulated in early-stage precursor disease provide an evolutionary trajectory that predisposes AA populations to greater risk and subsequent…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.