NIH R01 · 2024
Gene therapy methods for enhancing limb regeneration based on conserved transcriptional programs
Abstract: Adult teleost fish and urodele amphibians can regenerate entire amputated appendages, whereas this ability is restricted to the tip of the distal phalanx in humans and mice. Though modest in comparison to its zebrafish and salamander counterparts, mouse digit tip (MDT) regeneration exhibits similar anatomic stages and proceeds with intramembranous bone regrowth and mostly scarless healing, even in adults. By studying shared principles from organisms with elevated regenerative potential and applying them to mammalian models, we can gain valuable insight into strategies to augment human tissue repair and improve the care of limb loss patients. The catalogue of defined molecular…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.