NIH R01 · 2024
microRNA-controlled mRNA therapeutics
Nucleoside modified RNA-based drugs (modRNA) are a powerful new class of medicine. One type of modRNA, RNA vaccines, has been pivotal in immunization to SARS-CoV-2. modRNA is delivered via lipid nanoparticles (LNP), and antigen presented by whichever cells take up and expresses the modRNA. The identity and phenotypic state of cells presenting antigen directs how T cells become activated and differentiate. FDA-approved LNPs for modRNA delivery are not cell specific, resulting in expression in pAPCs, hepatocytes, myocytes, and other cells. The contributions of different transfected cell types to the immune response to modRNA-encoded proteins is not known. This is an important question because…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.