NIH R01 · 2024
PROJECT ABSTRACT Acute lymphoblastic leukemia (ALL) is the most common cancer diagnosed in childhood. Although survival rates for childhood ALL have improved in recent decades, ethnic disparities persist. Compared to most other ethnic groups, Latinos experience both a higher incidence of childhood ALL and poorer survival. The etiology of these disparities is complex and not fully understood, but ethnic-specific biological variability contributing to increased treatment-related toxicities are an important, under-studied cause of disparities in outcomes. For example, the antimetabolite agent methotrexate, a key component of curative ALL chemotherapy, results in dose-limiting clinical…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.