NIH R01 · 2025
HIV-OPN/SPP1Triad II: Molecular Pathways Regulating Neuronal-Glial Inflammation in the Brain
PROJECT SUMMARY The prevalence and incidence of neurological complications in people with HIV (PWH) remains steady for those aging on antiretroviral therapy (ART). Eliminating the tight association between chronic inflammation and HIV reservoirs in the periphery and CNS remain major therapeutic challenges. Elevated osteopontin/secreted phosphoprotein-1 (OPN/SPP1) in PWH having moderate to severe neurological complications was first reported in 2008. Since this time, the importance of high OPN/SPP1 RNA expression in human brain and more widely in neurodegenerative microglia has emerged. However, much remains to uncover about OPN/SPP1's fundamental basic molecular mechanism (s) of action in…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.