NIH R01 · 2024
Mechanoregulation of Ciliary Motility
Project Summary Mechanoregulation is a fundamental mechanism for the control of dynamic and multiscale biological systems. A mechanoregulatory network is responsible for the motility of cilia by converting the action of thousands of individual dynein motors bound to doublet microtubules in the cilium into a single waveform. This waveform has evolved to efficiently displace fluid, allowing either cell self-propulsion or the transport of extracellular liquid over epithelial surfaces. Ciliary motility in humans is therefore essential for the movement of sperm cells, the removal of bacteria and viruses from the respiratory tract, and the circulation of cerebrospinal fluid in the brain. Cilia…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.