NIH R01 · 2024
Effect of Maternal Exercise in Women with Obesity on Offspring Mesenchymal Stem Cell Metabolism
Project Summary Obesity in pregnancy increases the risk for excessive adiposity in offspring, which tracks into adulthood and can perpetuate across generations. Our preliminary data and published studies indicate that exercise initiated during pregnancy in sedentary women with obesity lowers infant BMI z-scores and body fat percentage. These benefits to infant health are more profound with resistance exercise during pregnancy. However, there are few mechanistic studies in humans aimed at discerning mechanisms of maternal exercise-induced changes to infant cellular metabolism. Our findings support the use of infant umbilical cord-derived mesenchymal stem cells (MSCs) as a model to explore…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.