NIH R01 · 2024
Preservation of muscle function through Schwann cell regulation of motor unit expansion
ABSTRACT. Preservation of muscle function through Schwann cell regulation of motor unit expansion The loss of skeletal muscle mass and function with aging, known as sarcopenia, is a universal health challenge for the growing elderly population, contributing to decreased mobility, increased disability, loss of independence, and poor quality of life. Studies from our group and others have shown that disruptions of muscle fiber innervation and a reduction in the number of motor units (MU) are significant factors in sarcopenia. A major compensatory mechanism that preserves muscle under conditions of denervation, is MU expansion, which requires axon sprouting and guidance from innervated to…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.