NIH R01 · 2024
The role of cyclin G1 and CDK5 in chronic kidney disease.
Summary: Chronic kidney disease (CKD) affects 10% of the world’s population and is characterized by progressive fibrosis and loss of kidney function, leading to end stage renal disease. Effective therapies to prevent or curtail the advancement of fibrosis remains a major clinical challenge. Kidney proximal tubule cells (PTC) have the remarkable ability to respond to injury by entering an earlier developmental state, termed dedifferentiation, and dividing to replace lost cells. PTCs then redifferentiate to resume normal function. For over 100 years, however, it has been known that a subset of PTCs never fully redifferentiate, and these chronically injured PTCs are a main driver of fibrosis…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.