NIH R01 · 2025
Dissecting innate immune control of intestinal and systemic Yersinia infection
Project Summary Infection by many pathogens leads to the formation of structures termed granulomas, organized clusters of macrophages, neutrophils, and lymphocytes, that contain and control the infection, but can also serve as sites for pathogen replication and dissemination. Infection by enteric Yersinia leads to the formation of pyogranulomas (PGs, granulomas enriched in neutrophils) in infected intestinal and systemic tissues. We recently reported that CCR2-dependent inflammatory monocytes are essential for acute control of Yp within infected sites, were required for formation of organized PGs, and were necessary for the activation of neutrophils and production of IL-1 cytokines within…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.