NIH R01 · 2025
Role of branched-chain fatty acids in physiology and virulence of Staphylococcus aureus
7. Project Summary/Abstract While some bacterial infections are caused by a single species, we now know that most infections are polymicrobial in origin. We know that the activities of these species are often synergistic, as interactions between species enhances virulence, persistence, and tolerance to antibiotics. The end result is patient outcomes are typically worse in co-infection compared to mono-infection. Staphylococcus aureus is the leading cause of skin and soft tissue infections. The bacterium is also the most common organism isolated from chronic wounds and is frequently found with the opportunistic pathogens Enterococcus faecalis and Pseudomonas aeruginosa. Interactions between…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.