Brinkley Lab

Research focus

NIH R01 · 2024

The POINTER Neurovascular Ancillary Study

PROJECT SUMMARY Age-related dysfunction of cerebral blood flow regulation plays an important role in the pathophysiology of brain aging and likely renders the aging brain more susceptible to the damaging effects of comorbid conditions, such as hypertension, diabetes, and hypercholesterolemia. Impairments in two key mechanisms that regulate cerebral blood flow at the local and systemic level (i.e., cerebral autoregulation and baroreflex sensitivity, respectively) may promote cerebral hypoperfusion in the course of normal activities of daily living, thereby setting the stage for repeated ischemic insults, progressive cognitive decline, and Alzheimer's disease and related dementias (ADRD).…

From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.