NIH R01 · 2025
Elucidating the role of the hyaluronan on PGC development and ovarian reserve establishment
ABSTRACT In mammals generally, including humans, the ovary ceases its functions little more than halfway through a female’s lifespan. This is strikingly different from the changes that occur in other organs, leading to a very long post-reproductive period in humans. Female reproductive aging is characterized by a loss of follicles; follicles are the functional units of the ovary, consisting of oocytes surrounded by companion granulosa cells. All the oocytes/follicles that the ovary will ever have will have been generated in utero or at a very early postnatal age. The study of ovarian reserve regulation has been very germ cell centric, relegating to a quite secondary role the ovarian stroma…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.