NIH R01 · 2025
Role of the SFTA2/ADGRF5 signaling axis in alveolar homeostasis
PROJECT SUMMARY Pulmonary alveolar homeostasis is dependent upon balanced airway and tissue surfactant pools. Alterations in alveolar surfactant pools are associated with inflammation and tissue destruction in severe lung diseases including acute respiratory distress syndrome, pulmonary alveolar proteinosis and genetic disorders of surfactant dysfunction. We have previously shown that the orphan G-protein coupled receptor ADGRF5 is a physiologically dominant molecular pathway within alveolar epithelial cells that regulates endogenous alveolar surfactant pools. The ability to pharmacologically modulate the ADGRF5 pathway, both positively and negatively, would be a major therapeutic advance…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.