NIH R01 · 2025
NDRGs as mediators of hypoxia adaptation
PROJECT SUMMARY Oxygen is essential for the life of many organisms, as it used during aerobic respiration to generate cellular energy in the form of adenosine triphosphate (ATP). Low oxygen (whether caused by environmental or cellular hypoxia) prevents adequate ATP production and can consequently cause cell death. Paradoxically, excessive oxygen, which often occurs post-hypoxia, is equally damaging, due to a surge in reactive oxygen species (ROS) that is damaging to biomolecules. Hence, aerobic organisms such as humans are susceptible to fluctuations in oxygen levels, which is manifested in many disease states, including chronic kidney disease, acute kidney injury, sickle cell anemia and…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.